CURRICULUM VITAE

Name:  Gregory E. Lakin, M.D.

Position/Title:  University of Rochester Division of Plastic Surgery Resident

Email: Gregory_Lakin@URMC.Rochester.Edu

Duke University, Durham, NC                              B.S.     1998               Biology, Spanish

Duke-in-Spain Program, Madrid, Spain                            5/-7/96            Spanish

Duke-in-the-Andes Program, La Paz, Bolivia                   8-12/96           Spanish

Universidad Autónoma de Guadalajara, Mexico              1998-2001      Medicine

Ponce School of Medicine, Ponce, Puerto Rico    M.D.   2004                Medicine

University of Rochester, Rochester, NY                           2004-2007      General-Plastic Surgery Residency

University of Pennsylvania and Children’s

Hospital of Philadelphia, Philadelphia, PA                       2007-2009      Craniofacial Research Fellowship

University of Rochester, Rochester, NY                           2009-2011      General-Plastic Surgery Residency

University of California, Los Angeles (UCLA)                2011-2012      Craniofacial Surgery Fellowship

Postgraduate Training and Fellowship Appointments

July 2004—June 2005            Intern, Combined General-Plastic Surgery Residency, Strong Memorial Hospital, University of Rochester School of Medicine, Rochester, NY

July 2005—June 2007            Resident, Coordinated General-Plastic Surgery Residency, Strong Memorial Hospital, University of Rochester School of Medicine, Rochester, NY

July 2007—June 2009            Research Fellow, Division of Plastic Surgery, University of Pennsylvania School of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA

July 2009—June 2011            Resident, Coordinated General-Plastic Surgery Residency, Strong Memorial

       (Expected)           Hospital, University of Rochester School of Medicine, Rochester, NY

July 2011—June 2012            Fellow, Craniofacial Surgery, Division of Plastic Surgery, University of

                   (Expected)           California, Los Angeles (UCLA)

Previous Research Experience

1993                University of Florida’s Florida Foundation for Future Scientists (FFFS) High School Summer Student Science Training Program (SSTP), Gainesville, FL

                        Studied alligator infertility

                        PI: Paul Cardeilhac, Ph.D.

1995, 1997      University of Miami School of Medicine Division of Surgical Oncology, Miami, FL

Studied stereotactic breast cancer therapy and breast cancer in pregnancy

            PI: David Robinson, M.D.

1997-1998       Duke University Biological Laboratories Independent Study Program, Durham, NC

            Studied evolutionary phylogenetic reconstruction

            Supported by Duke University Undergraduate Research Support Grant

PI: John Mercer, Ph.D.

2002                University of Texas MD Anderson Cancer Center Surgical Oncology, Medical Student Summer Research Program, Houston, TX

Studied gene therapy for breast cancer and angiosarcoma of the breast

PI’s: Kelly Hunt, M.D. and Janice Cormier, M.D., M.P.H.

2007-2009       University of Pennsylvania Plastic Surgery Research Fellowship, Philadelphia, PA

Studied the role of mechanical stress on craniosynostosis, cleft palate gene therapy, molecular regulation of palatogenesis, influence of maggot secretions on impaired wound healing, and tissue engineering for craniofacial defects

Supported by the University of Pennsylvania Center for Human Appearance and The Children’s Hospital of Philadelphia Children’s Surgical Associates

            PI’s: Richard Kirschner, M.D. and Hyun-Duck Nah, D.M.D., Ph.D.

2009-2011       University of Rochester Division of Plastic Surgery, Rochester, NY

                        Conducting a meta-analysis of twins and craniosynostosis (PI: Dr. John Girotto, M.D.), microarray analysis of twins with craniosynostosis (PI: Dr. John Girotto, M.D.), studying chicken thigh model for microsurgical skills lab (PI: Dr. Howard Langstein), and studying the growth profiles in cleft children and adolescents (PI: Dr. John Girotto, M.D.)

Publications

Peer-Reviewed Journal Articles

1.      Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PWT, Ballo MT, Chen L, Trent J, Burgess M, Patel S, Pollock RE, Cormier JN. Angiosarcoma of the breast. Cancer. 2005; 104: 2682-2688.

2.      Lakin GE, Wu C, Salhab I, Zajac A, Traas J, Dienno JJ, Davis P, Bergelson JM, Zoltick PW, Kirschner RE, Nah HD. Overexpression of IRF6 Rescues the Tfgb3^-/- Fetal Mouse Palatal Fusion Defect. Manuscript in preparation to be submitted to Development.

3. Lakin GE, Sinkin J, Koltz PF, Girotto JA. Twins and Craniosynostosis: A Systematic Review and Meta-Analysis. Manuscript in preparation to be submitted to Plastic and Reconstructive Surgery.
4. Koltz PF, Fargione RA, Lakin GE, Girotto JA. Assessment of Growth Profiles in Cleft Children and Adolescents. Manuscript in preparation to be submitted to Cleft Palate Craniofacial Journal.
5. Laurita JT, Lakin GE, Chin BC, Nah HD. Muenke mutation (FgfR3P244R) causes premature ossification of basicranial synchondrosis cartilage and shortening of the cranial base in a knock-in mouse model. Manuscript in preparation.
   
   

Abstracts

1.      Robinson DS, Lentz J, Moffat F, Franceschi D, Beber B, Korensky T, Lakin GE.  The Role of Stereotactic Mammographically Directed Core Biopsy for Non-Palpable Breast Lesions:  A Single Institutional Analysis of 196 Procedures.  University of Miami School of Medicine Surgical Oncology and Radiology, Miami, Florida 1995.

2.      Spivak RM, Endo M, Zajac A, Zoltick PW, Lakin GE, Flake AW, Kirschner RE,  Nah HD. In Utero Delivery of Virally Encoded TGF-beta3 Rescues Cleft Palate in the TGF-beta3 Knockout Mouse. Presented at the 87^th Annual Meeting of the American Association of Plastic Surgeons in Boston, MA, April 5-8, 2008.

3. Lakin GE, Spivak RM, Zajac A, Dienno JJ, Davis PF, Zoltick PW, Kirschner RE, Nah HD. Adenovirus Encoding the IRF6 Gene Partially Rescues the Fusion Defect in a TGF-beta3-/- Mouse Embryonic Palatal Organ Culture. Presented at the 65^th Annual Meeting of the American Cleft Palate-Craniofacial Association in Philadelphia, PA, April 14-18^th, 2008.

4.      Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. The Molecular Regulation of Palatogenesis: Adenovirus-Mediated IRF6 Transduction of the Medial Edge Epithelium Rescues the Fusion Defect of the TGF-beta3-/- Mouse Palate in Organ Culture. Presented at the 25^th Annual Meeting of the Northeastern Society of Plastic Surgeons in Philadelphia, PA, October 2-5, 2008.

5.      Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. Discovery of a New Molecular Pathway in Palatogenesis: IRF6 is an Important Downstream Effector of TGF-beta3 Signaling in Palatal Fusion. Presented at the 88^th Annual Meeting of the American Association of Plastic Surgeons in Rancho Mirage, CA, March 21-25, 2009.

6.      Wu C, Radecki A, Lakin GE, Salhab I, Flake AW, Kirschner RE, Nah HD. Intra-amniotic delivery of an adenoviral vector expressing TGFβ3 rescues palatal fusion defect in TGFβ3 null mice. Presented at the Annual Meeting of the Philadelphia Academy of Surgery in Philadelphia, PA, February 2, 2009.

7.      Lakin GE, Zoltick PW, Salhab I, Kallewaard NL, Bergelson JM, Kirschner RE, Nah HD. Overexpression of IRF6 in the Medial Edge Epithelium of Embryonic Palatal Shelves Rescues the Fusion Defect in a TGF-b3-/- Mouse Palate in Organ Culture. Presented at the 19^th Annual Children’s Hospital of Philadelphia Research Poster Day in Philadelphia, PA, February 25^th, 2009.

8.      Lakin GE, Dienno JJ, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Coxsackievirus and Adenovirus Receptor Expression Correlates with Adenoviral Tropism Towards the Embryonic Mouse Palate. Presented at the 55^th Annual Meeting of the Robert H. Ivy Society of Plastic Surgeons in Pittsburgh, PA, April 17-18, 2009.

9.      Lakin GE, Dienno JJ, Yang BH, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Adenoviral Tropism Towards the Medial Edge Epithelium of the Embryonic Mouse Palatal Shelf Correlates with Coxsackievirus and Adenovirus Receptor (CAR) Expression. Presented at the 66^th Annual Meeting of the American Cleft Palate-Craniofacial Association in Scottsdale, AZ, April 20-25, 2009.

10.  Wu C, Lakin GE, Radecki A, Endo M, Kirschner RE, Nah HD. In Utero Somatic Transfer of TGFB3 and IRF6 Genes Rescues TGFb3^−/− Induced Palatal Fusion Defects in Mice. Accepted for presentation at the 11^th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies in Fortaleza, Brazil, September 10-13, 2009.

11.  Wu C, Yang BH, Lakin GE, Radecki MA, Kirschner RE, Nah HD. IRF6 as a Downstream Effector of TGFB3  Signaling in Palatogenesis: In Utero Somatic Delivery of Ad-IRF6 Rescues the Palatal Fusion Defect in TGFB3 Mice. Accepted for presentation at the 26^th Annual Meeting of the Northeastern Society of Plastic Surgeons in Charleston, SC, Sept 23-27, 2009.

12.  Lakin GE, Salhab I, Dienno JJ, Yang BH, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Identification of a Target Receptor for Adenoviral Mediated Gene Delivery to the Palate: The Coxsackievirus and Adenovirus Receptor (CAR). Presented at the 26^th Annual Meeting of the Northeastern Society of Plastic Surgeons in Charleston, SC, Sept 23-27, 2009.

13.  Wu C, Lakin GE, Yang BH, Salhab I, Kirschner RE, Nah HD. IRF6 as a Downstream Effector of TGFB3 Signaling in Palatogenesis: In Utero Somatic Delivery of Ad-IRF6 Rescues the Palatal Fusion Defect in TGFβ^−/− Mice. Presented at the 13^th Biennial International Congress of the International Society of Craniofacial Surgery in Oxford, UK, September 26-30, 2009.

14.  Lakin GE, Sinkin JC, Koltz PF, Girotto JA. Craniosynostosis in Twins: A Systematic Review and Meta-Analysis. Presented at the 67^th Annual Meeting of the American Cleft Palate-Craniofacial Association in Fort Worth, TX, March 15-20, 2010.

15.  Fargione RA, Koltz PF, Lakin GE, Girotto JA. Assessment of Growth Profiles in Cleft Children and Adolescents. Presented at the 67^th Annual Meeting of the American Cleft Palate-Craniofacial Association in Fort Worth, TX, March 15-20, 2010.

16.  Lakin GE, Salhab I, Dienno JJ, Yang BH, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD.  Detection of a Target Receptor for Adenoviral Mediated Gene Delivery to the Palate: The Coxsackievirus and Adenovirus Receptor (CAR). Presented at the 89^th Annual Meeting of the American Association of Plastic Surgeons resident poster competition in San Antonio, TX, March 20-23, 2010.

17.  Koltz PF, Fargione RA, Lakin GE, Girotto JA. Assessment of Growth Profiles in Cleft Children and Adolescents. Accepted for presentation at the 55^th Annual Meeting of the Plastic Surgery Research Council in San Fransisco, CA, May 22-26, 2010.

18.  Laurita JT, Lakin GE, Chin BC, Nah HD. Muenke mutation (FgfR3P244R) causes premature ossification of basicranial synchondrosis cartilage and shortening of the cranial base in a knock-in mouse model. Presented at the 27^th Annual Meeting of the Northeastern Society of Plastic Surgeons in Washington, D.C., October 28-31, 2010.

19.  Lakin GE, Girotto JA, Bloom JM, Herrera RH, Langstein HN. Validation of a Microsurgical Skills Lab: A New Paradigm to Train Microsurgery. Accepted to the 90^th Annual Meeting of the American Association of Plastic Surgeons resident poster competition in Boca Raton, FL, April 9-12, 2011.

Book Chapters

1.      Robinson DS, Sundaram M, Lakin GE.  “Carcinoma of the breast in pregnancy and lactation.”  In Bland KI, Copeland EM (eds):  The Breast:  A Comprehensive Textbook for the Management of Benign and Malignant Diseases.  Second Edition, Philadelphia, WB Saunders, 1998, pp 1433-1445.

2.      Robinson DS, Sundaram M, Lakin GE.  “Carcinoma of the breast in pregnancy and lactation.”  In Bland KI, Copeland EM (eds):  The Breast:  Comprehensive Management of Benign and Malignant Diseases.  Third Edition, Philadelphia, WB Saunders, 2004, pp 1475-1490.

Grants

1.      Lakin GE, Nah HD, Kirschner RE. “Influence of Mechanical Stress on Muenke Syndrome Craniosynostosis.” 2008 Plastic Surgery Educational Foundation Basic Research Grant Award Recipient

2.      Lakin GE, Bartlett S, Nah HD, Kirschner RE. “Influence of Mechanical Stress on the Phenotypic Variability of Muenke Syndrome Craniosynostosis.” 2008 American Society of Maxillofacial Surgeons/Maxillofacial Surgeons Foundation & Synthes CMF Research Grant Award Recipient

3.      Lakin GE, Nah HD, Kirschner RE. “Muenke Syndrome Craniosynostosis: Influence of Biomechanical Stress on Phenotypic Variability” Submitted to the 2008 Cleft Palate Foundation, Children’s Craniofacial Association Research Grant, Not awarded, Finished second place.

4.      Lakin GE, Wu C, Liechty KW, Nah HD, Kirschner RE.  “The Influence of Maggot Secretions on the Healing of Impaired Wounds.” Submitted to 2009 Plastic Surgery Educational Foundation Wound Care Fellowship. Not awarded.

Animal Protocol

2008-Present   Lakin GE. The Children’s Hospital of Philadelphia, The Joseph Stokes, Jr. Research Institute. “Microsurgical Skills Lab using Euthanized Rats” Principle Investigator, Hyun-Duck Nah.

Honors and Awards

2010                American Society of Maxillofacial Surgeons Resident Scholar

2010                American Association of Plastic Surgeons 3^rd Place Resident Poster Competition

2010                Co-chair of Junior Investigator Competition at the 67^th Annual Meeting of the American Cleft Palate-Craniofacial Association in Fort Worth, TX, March 15-20, 2010

2010                Top Gun Award, highest percentile rank on ASPS in-service exam among Rochester residents

2010                American Society of Plastic Surgeons Grand Rounds Mentorship Program–Craniofacial Surgery

2009                American Society of Plastic Surgeons Grand Rounds Mentorship Program–Craniofacial Surgery

2009                American Cleft Palate-Craniofacial Association Paul W. Black Junior Investigator Award

2008                American Society of Maxillofacial Surgeons/Maxillofacial Surgeons Foundation Research Grant Award

2008                Plastic Surgery Educational Foundation Basic Research Grant Award

2004                Ponce School of Medicine, M.D. with clinical distinction

2004                Who’s Who Among Students in American Universities and Colleges, Ponce School of Medicine

Professional Memberships

1999-Present   American Medical Students Association (National Positions: Board of Trustees International Trustee, Liaison to Educational Commission for Foreign Medical Graduates, Membership Benefits Committee, House of Delegates Reference Committee, Membership Recruitment and Fall Conference Committee 2001-2002; Resident Member 2004-Present)

2004-Present   American College of Surgeons, Candidate Group Member

2007-Present   American Society of Plastic Surgeons, Resident Member (Grand Rounds Mentorship Program 2009, Resident Coordinator 2008)

2008-Present   American Cleft Palate and Craniofacial Association, Resident Member

2008-Present   American Society for Reconstructive Transplantation, Trainee Member      

2008-Present   Northeastern Society of Plastic Surgeons, Resident Member

2008-Present   Robert H. Ivy Society of Plastic Surgeons, Resident Member

2008-Present   American Society of Maxillofacial Surgeons, Resident Affiliate Member

Other Presentations

2010                Grand Rounds, University of Rochester Division of Plastic Surgery, Fat Grafting: Basic Science and Clinical Innovations

2009                Grand Rounds, University of Rochester Division of Plastic Surgery, Transplant Immunology 101

2009                Grand Rounds, University of Pennsylvania Division of Plastic Surgery Lab Fellows Talk

2008                Grand Rounds, University of Pennsylvania Division of Plastic Surgery Lab Fellows Talk

2008                Invited Speaker, The Children’s Hospital of Philadelphia Pathology Core Laboratories

The Molecular Regulation of Palatogenesis:  IRF6 is an Important Downstream Effector of TGFβ3 Signaling in Palatal Development

Hospital Appointments

2008-2009       Chestnut Hill Hospital General Surgery Moonlighter, Philadelphia, PA

2007-2009       Children’s Hospital of Philadelphia Trauma Surgery Moonlighter, Philadelphia, PA

2007-2009       Main Line Health Lankenau Hospital General Surgery Moonlighter, Wynnewood, PA

2007-2008       Penn Presbyterian Medical Center Urology & Gynecology Moonlighter, Philadelphia, PA

Other Experiences

1995-1996       Duke University Varsity Cross Country/Track Team

1997 – 1998    Spanish Interpreter, Duke University Medical Center, Durham, NC

1998-2004       Medical School Class Notes Service http://greglakin.tripod.com

1999-2000       Clinical Trustee for North America, North American Students Association, Universidad Autonoma de Guadalajara

1999-2000       Founder and Chair, Fifth Pathway Committee, Universidad Autonoma de Guadalajara

2000 – 2001    Medschool.com International Medical Education Discussion Forum Moderator

2000-2001       Class Vice-President, Universidad Autonoma de Guadalajara

2001-2002       Senator, Academic Senate, Ponce School of Medicine

2001-2002       Student Representative, Liaison Committee on Medical Education, Ponce School of Medicine

2003-2004       President, Surgery Interest Group, Ponce School of Medicine

2006-2007       Member, Patient Safety Committee, University of Rochester

2007-2009       Coordinator, Microsurgery Skills Laboratory (Rat model), University of Pennsylvania

2009-2010       Member, Surgical Education Committee, University of Rochester

2009-2010       Coordinator, Microsurgery Skills Laboratory (Chicken model), University of Rochester